iS Clinical serums are formulated with pharmaceutical-grade ingredients and clinically proven actives designed to deliver visible results across a range of skin concerns. Whether you are targeting the appearance of fine lines, uneven texture, or dull-looking skin, each serum in this collection is developed to support the appearance of healthier, more radiant-looking skin.

At the core of the collection is Active Serum, a multi-concern formula trusted by skincare professionals worldwide. This cult-classic serum combines botanically derived acids with powerful antioxidants to visibly refine skin texture and support a clearer-looking complexion. For targeted Vitamin C support, Pro-Heal Serum Advance+ delivers pharmaceutical-grade L-Ascorbic Acid formulated for optimal stability and absorption.

Advanced anti-aging support begins with Super Serum Advance+, a growth factor serum that supports the appearance of firmer, smoother-looking skin. For lightweight hydration, Hydra-Cool Serum provides multi-weight Hyaluronic Acid to replenish moisture at multiple levels.

Every iS Clinical serum reflects the brand's commitment to formulation excellence — high-grade botanical ingredients paired with pharmaceutical-grade actives at concentrations that matter. Trusted by dermatologists and estheticians in 60+ countries, these formulations fit seamlessly into the Treat step of the Cleanse, Treat, Hydrate, Protect regimen.

Explore the full Vitamin C collection for brightening-focused serums, or discover your ideal regimen with the skincare recommendation quiz.