iS Clinical sunscreens combine mineral UV protection with clinically proven actives, delivering broad-spectrum defense that goes beyond basic sun protection. Formulated with pharmaceutical-grade ingredients and advanced antioxidants, each sunscreen in this collection is designed to protect while supporting the appearance of healthier-looking skin.

Eclipse SPF 50+ is a lightweight, non-greasy mineral sunscreen available in both tinted and untinted formulations. Trusted by skincare professionals worldwide, Eclipse SPF 50+ provides broad-spectrum UVA/UVB protection with an elegant finish suitable for daily wear under makeup or alone. For enhanced treatment benefits, Extreme Protect SPF 30 combines mineral and microencapsulated chemical UV filters with Extremozyme technology to help shield fragile proteins and DNA components while supporting overall skin resilience.

Additional options include Extreme Protect SPF 40 for fully physical protection with the same treatment-level formulation, and PerfecTint Powder SPF 40, a brush-on mineral powder ideal for midday touch-ups and on-the-go reapplication. For lip protection, LIProtect SPF 35 delivers targeted UV defense for the lip area.

Every iS Clinical sunscreen reflects the Protect step of the Cleanse, Treat, Hydrate, Protect regimen — the essential final step in any professional-grade skincare routine. These formulations are designed to layer seamlessly over serums and moisturizers without pilling or heaviness.

Build your complete regimen with the skincare recommendation quiz, or explore the moisturizers collection for hydration to pair with your sun protection.